250 years of US innovation

9 Jun 2026

Ulrike Hoffmann-Burchardi, Chief Investment Officer Americas and Global Head of Equities; Eric Potoker, Equity Strategist, Healthcare, CIO Americas; Kurt Reiman, Head of Fixed Income, CIO Americas

Scientific progress often begins by combining what had previously remained separate. In the case of recombinant DNA, that meant joining genetic material from different organisms to produce something new. The discovery of rDNA in the 1970s enabled therapies that would transform medicine and launch the biotechnology industry. It was a literal form of union—one that expanded what science could do, even as it raised questions about what it should do.

From the outset, those risks were not theoretical. Early pioneers, led by Paul Berg, recognized that recombinant DNA could produce unintended and potentially dangerous outcomes. Rather than advance unchecked, the scientific community called for a pause. The 1975 Asilomar Conference did not eliminate uncertainty, but it established a framework to manage it—defining containment standards and acceptable lines of inquiry before large-scale experimentation resumed.

The commercial implications followed quickly. Genentech’s development of humanized insulin, and later monoclonal antibody therapies, expanded treatment options and drew significant investment into biotechnology. But as the field scaled, so too did the complexity of its risks, extending beyond laboratory safety to questions of access, intellectual property, and the pace of clinical adoption. Technologies that followed—gene editing, cell therapies, RNA-based vaccines—continue to build on rDNA while raising similar questions in new forms.

Recombinant DNA illustrates that progress is not simply a function of discovery, but of how that discovery is governed. The same act of combining genetic material that made new therapies possible also introduced risks that required collective restraint. As new applications emerge, the precedent set at Asilomar remains relevant—not as a finished solution, but as an example of how a scientific community acted before the full implications were clear. Similar questions are now emerging around artificial intelligence, where capability is advancing faster than the systems designed to oversee it.

5 May 2026

Ulrike Hoffmann-Burchardi, Chief Investment Officer Americas and Global Head of Equities; Kevin Dennean, Equity Strategist, Tech & Telecom, CIO Americas; Kurt Reiman, Head of Fixed Income, CIO Americas

Transformational innovations expand human capability but also introduce new forms of dependence. The smartphone exemplifies this pattern: It loosened the grip of location on communication, information, and services, while pulling daily life more tightly into digital systems that are always within reach. 

The smartphone emerged from a mobile industry that was already large, competitive, and fragmented. By the mid-2000s, leading handset makers and enterprise devices coexisted with multiple operating systems and competing approaches to “smart” functionality, without a single standard for mobile computing at scale.

The turning point was the shift from device to platform. Once software distribution and developer economics became central, scale created a flywheel: users attracted developers, developers created new services, and those services reinforced adoption. 

The practical freedoms were concrete. Capabilities that once depended on fixed locations or dedicated tools—navigation, media, and many forms of coordination—moved onto a single device people already carried, while the app ecosystem rewired entire categories around software rather than standalone hardware. 

The downside is captured in a simple contradiction, as the same forces that expanded access also concentrated power and attention. Platform economics narrowed the field of viable operating systems to two mass ecosystems, and switching costs rose as users accumulated apps, subscriptions, and data inside tightly integrated environments. Many now argue that always available apps and social feeds make disconnecting harder, and that responses—from usage management features to regulation—remain inconsistent. 

That contradiction matters even more as the next platform shift unfolds. Smartphones are positioned to become the primary interface for generative AI embedded at the operating system layer, with the dominant platforms controlling the “last mile” of the user relationship and the ability to deploy AI agents across daily workflows on a global scale. In that sense, our report title’s irony is instructive rather than gloomy: The smartphone delivered genuine freedom from location, and the next wave will test how societies extend that freedom while managing the responsibilities that come with concentrated, always present systems.

9 Apr 2026

Ulrike Hoffmann-Burchardi, Chief Investment Officer Americas and Global Head of Equities; Jeff Harwood, Equity Strategist, Financials CIO Americas; Kurt Reiman, Head of Fixed Income, CIO Americas

Transformational innovations are often defined less by the object itself than by the systems they enable. Credit cards are no exception. What began as a simple piece of plastic evolved into a global payments infrastructure that reshaped commerce, consumer behavior, and financial intermediation. Like many enduring American innovations, their success rested not on a single breakthrough, but on the gradual construction of networks, standards, and trust.

Early attempts to extend credit at scale were fragmented and local. Department store charge accounts, travel cards, and bank-issued experiments operated in closed loops, limiting their reach and usefulness. The decisive shift came when banks and merchants aligned around interoperable networks that allowed credit to travel—across stores, cities, and eventually borders. The emergence of nationwide card associations transformed isolated lending relationships into a shared system, enabling transactions to clear quickly and reliably between parties with no prior relationship.

Technology reinforced this progress incrementally rather than all at once. Magnetic stripes, electronic authorization, and later embedded chips each addressed specific frictions—speed, accuracy, and security. None was revolutionary on its own. Together, they allowed card payments to scale, reducing transaction costs for merchants and expanding access for consumers. These advances shifted payments away from cash and checks toward electronic settlement, quietly increasing efficiency and economic velocity.

The expansion of credit card networks coincided with a broader transformation of the US economy. Easy access to revolving credit supported household consumption and helped smooth spending. Merchants benefited from guaranteed payment and broader customer reach. Governments also benefited, as more activity moved into the formal economy. As with railroads and electrification, the greatest gains accrued not only to the innovators themselves, but to the businesses and households that adopted the new infrastructure.

Yet the rise of credit cards also illustrates a recurring tension in transformational innovation. Systems designed to expand access and convenience may also introduce new risks, from over-indebtedness to market concentration. In The Graduate, the famous line about “a great future in plastics” captures a moment when optimism runs ahead of reflection. Similar tensions have periodically drawn regulatory scrutiny and competitive responses in the credit card industry, forcing adaptation rather than complacency.

Credit cards ultimately remind us that transformational innovation does not always look transformative at first. A thin piece of plastic—cheap, standardized, and easily overlooked—became the interface to a far more powerful system beneath it. The plastic ultimately mattered less than the networks and trust it represented, illustrating how something deceptively ordinary can compound through scale and coordination into infrastructure that quietly reshapes the economy.

Top of the Morning: 250 years of US innovation - Credit Cards

28 Apr 2026  |  9 min

The seventh edition of CIO’s 250 years of US innovation series, A great future in plastics, examines how credit cards evolved from a simple piece of plastic into a global payments infrastructure. Our conversation explores how networks, technology, and trust transformed everyday transactions, reshaping commerce and the modern economy. Featured is Jeff Harwood, Financials Equity Strategist Americas, UBS Chief Investment Office. Host: Daniel Cassidy

12 Mar 2026

Ulrike Hoffmann-Burchardi, Chief Investment Officer Americas and Global Head of Equities; Kevin Dennean, Equity Strategist, Tech & Telecom, CIO Americas; Kurt Reiman, Head of Fixed Income, CIO Americas

E pluribus unum—“out of many, one”—has long described the American experiment. It also offers a useful way to understand one of the most consequential innovations of the modern era: the internet. Like many transformational technologies before it, the internet did not arrive fully formed, nor was it the product of a single inventor or institution. Instead, it emerged from a dispersed network of researchers, engineers, entrepreneurs, universities, government agencies, and private firms, each contributing pieces that only later cohered into something greater than the sum of its parts.

From early work on packet switching and networking at research labs and universities, to the development of shared protocols such as TCP/IP, progress was uneven, iterative, and often uncoordinated. Yet agreement on common technical standards allowed these disparate efforts to interconnect. Out of many independent systems arose one global network. This was not unity imposed from the top down, but unity achieved through voluntary cooperation—a hallmark of both American innovation and the internet’s enduring design.

That architecture remains central today. The internet is a single global network precisely because it is decentralized. Countless independently owned and operated networks follow shared rules that allow data to flow seamlessly across borders, institutions, and devices. No central authority controls it in its entirety, yet it functions as a unified system. Its resilience, scalability, and speed stem from this structure, much as earlier infrastructure revolutions—from railroads to electrification—benefited from standardization layered atop diversity.

The economic consequences have been profound. By dramatically reducing the cost of communication, coordination, and information exchange, the internet accelerated globalization and reshaped trade. Firms gained access to global customers and suppliers in real time. Supply chains became more integrated, services more tradable, and capital more mobile. Digital platforms lowered barriers to entry, allowing smaller businesses and entrepreneurs to participate in global commerce in ways that once required vast physical infrastructure. As with past general-purpose technologies, the internet did not merely improve existing markets—it created entirely new ones.

In that sense, the internet stands firmly in the lineage of America’s great innovations. From many innovators, many networks, and many competing visions emerged a single global system—one that continues to reshape trade, productivity, and economic integration. Out of many, one.

Top of the Morning: 250 years of US innovation - The internet

28 Mar 2026  |  12 min

The sixth edition of CIO’s 250 years of US innovation series, E pluribus unum, shows how the internet’s decentralized, standards-based architecture unified innovators, accelerated globalization, reshaped trade, and created new opportunities for businesses and individuals worldwide. Featured is Kevin Dennean, Technology & Telecom Equity Strategist Americas. Host: Daniel Cassidy

19 Feb 2026

Ulrike Hoffmann-Burchardi, Chief Investment Officer Americas and Global Head of Equities; Kayden Lee, Equity Strategist, CIO APAC; Kurt Reiman, Head of Fixed Income, CIO Americas; Delwin Limas, Equity Strategist, CIO APAC

For many, the mythology of the information technology sector’s rise begins in a modest garage somewhere in the neighborhood of Menlo Park or Santa Clara, California. But that’s not quite how it all started. 

Before Silicon Valley became today’s hub, or central processing unit, for technology, there were numerous foundational discoveries dotting the US landscape along the way. For example, in the 1940s and 1950s, scientists at Bell Labs—a subsidiary of the telecommunications giant AT&T headquartered in central New Jersey—spearheaded much of today’s research into early transistors. A few years later and thousands of miles to the south in Dallas, Texas, researchers at a much smaller firm, originally founded for oil exploration, developed the first commercially viable silicon-based transistor. That breakthrough paved the way for that small firm to become one of the early titans of the microchip: Texas Instruments. Then, back on the Pacific Coast in Palo Alto, California, the first commercially viable integrated circuit was born at a company called Fairchild Semiconductor. Robert Noyce and Gordon Moore resigned from Fairchild to found Intel Corporation in 1968.

The early semiconductor industry was highly reliant on federal government policy and financial support, especially for defense and aerospace, to achieve scale and ultimately realize resounding commercial success. Government assistance of transformational technologies is nothing new. It played a large role in the building of the transcontinental railroad (Issue 1, 27 October 2025) and the viability of commercial aviation (Issue 3, 17 December 2025). Private-sector sales of semiconductors dominate today, but the industry benefited from government procurement to provide a kickstart.

After having lost substantial market share to Japanese producers of memory chips in the 1980s, the US sought and achieved market access concessions from Japan in 1986 in exchange for export restraints. The US government is once again actively working to revive some of the early dynamism of semiconductor production, exemplified by initiatives like the 2022 Creating Helpful Incentives to Produce Semiconductors (CHIPS) for America Act. International competition to stay ahead in the artificial intelligence (AI) arms race, the harsh realities of supply bottlenecks during COVID-19, and the susceptibility to losing access to the critical minerals needed to manufacture semiconductors are all factors driving today’s policy decisions.

Ahoy, the AI race is on, helping to spur additional spending on semiconductor research, manufacturing, and design. The US semiconductor industry remains at the cutting edge of chip design, but it lags in manufacturing capabilities. While there is much anticipation about the future for semiconductors, nearly 70 years after their initial discovery, there is also no room for complacency.

Top of the Morning: Chips Ahoy - The semiconductor

27 Feb 2026  |  19 min

The 250 years of US innovation publication series highlights examples of how transformational innovation has been an engine of US economic growth since the nation’s founding. Today, we explore the history and application of the semiconductor and microchip. Featured are Kurt Reiman, Head of Fixed Income Americas, and Kevin Dennean, US Technology & Communications Services Equity Sector Strategist, UBS Chief Investment Office. Host: Daniel Cassidy

27 Jan 2026

Ulrike Hoffmann-Burchardi, Chief Investment Officer Americas and Global Head of Equities; Kurt Reiman, Head of Fixed Income, CIO Americas; Sunny Mehra, Equity Strategist, Consumer CIO Americas

Transformational innovation takes many forms. Often it emerges as a shiny, new product, like the incandescent lightbulb or the airplane, creating a before-and-after moment for everyone who encounters it. Steady refinements and advances in the product throughout its lifecycle help spur adoption and scale. Other times, innovation lies in the process. The discovery is not the product, per se, but rather in how it transforms productivity. The assembly line is a prime example of this “process” enhancement.

Meatpacking is often cited as a precursor to the assembly line given that it, too, relied on specialized labor and uniform inputs. However, these “disassembly” lines were powered by bulky, inefficient, and often hazardous steam engines to move a single conveyor belt.

The advent of electrification in the late 1800s heralded a shift away from steam to electric motors, but what it needed were visionaries to spur broader application. Even by 1910, electric motors were rarely used in manufacturing, despite their promise of modularity in product design and speed control at each stage of the process. This was the unique nature of Henry Ford's vision for the assembly line: bringing work to the worker using electricity to accelerate and control the production flow while  specializing labor and standardizing components to reduce costs. 

In 1913, the automobile was in its infancy. Only the truly well-heeled could afford one. For cars to become a mass-market product, Henry Ford knew that he would have to radically transform the production process to make them affordable. The assembly line boosted automobile output at much lower prices, leading to consumer surplus, steady employment, and reliable benefits throughout working life and retirement.

Even though the assembly line improved overall prosperity, it also led to the deskilling of workers, resulting in widespread job dissatisfaction and lost craftsmanship. Today, artificial intelligence (AI) and automation are having the opposite effect: disintermediating jobs with repetitive tasks, while increasing the value of specialization and once again promising to boost productivity.

As before, investing in transformational technologies requires a diversified set of exposures and an understanding of how the technology will shape the macro and political economies. Moreover, owning the application layer is every bit as important as the infrastructure layer. As we saw with electricity and the assembly line, one transformational technology can beget another. This lesson is instructive as we seek investment opportunities related to AI and automation.

Top of the Morning: Made in USA - The assembly line

27 Jan 2026  |  15 min

The 250 years of U.S. innovation publication series highlights examples of how transformational innovation has been an engine of U.S. economic growth since the nation's founding. Today, we explore the history of the assembly line in the U.S. by referencing the next publication of the series: Made in USA - The assembly line. Featured are Kurt Reiman, Head of Fixed Income Americas, and Sunny Mehra, U.S. Consumer Sector Strategist, UBS Chief Investment Office. Host: Daniel Cassidy

17 Dec 2025

Ulrike Hoffmann-Burchardi, Chief Investment Officer Americas and Global Head of Equities; Kurt Reiman, Head of Fixed Income, CIO Americas; Nathaniel Gabriel, Equity Strategist, Industrials & Materials, CIO Americas

There are few moments in the history of American innovation as iconic as the Wright brothers’ first flight on the Outer Banks of North Carolina in 1903. Anyone who has ever visited the wind-swept, sand dunes of Kitty Hawk can only imagine their feat: traveling 120 feet in 12 seconds in a 750-pound aircraft (pilot included) with a 12-horsepower, custom-built, four-cylinder gasoline engine.

Blimps, balloons, and airships were already in operation during the mid-1800s, but they flew on the principle of buoyancy (lighter than air). The Wright Flyer achieved lift even though it was heavier than air. The engine provided the propulsion, but the Wrights managed to achieve sustained flight because their flyer integrated an improved wing design informed by testing in their own wind tunnel and by incorporating three-dimensional controls crucial to aerodynamics: pitch (front to back), yaw (side to side), and roll (top to bottom).

Having conquered the perilous and complex geography of the US with the building of the transcontinental railroad some 34 years earlier, American engineers, entrepreneurs, and innovators turned their gaze toward the skies with the invention of the airplane. Both the railroad and aviation benefited from federal legislation and governmental financial backing. Government procurement of airplanes during World War I gave the infant industry an initial early jolt and the resources to innovate. The postal service became the industry’s next large customer in the 1920s through an act of Congress.

Unlike the railroad, where the technology was already in place and the major achievement was the formidable investment in infrastructure, the success of aviation required iterative, technologically driven innovation flowing from research and development labs in the private and public sectors as well as academia. Steady improvements in range, altitude, speed, safety, and reliability spurred a growing revenue stream from commercial airlines to service paying passengers in the 1930s before the military once again became the dominant force in the airplane industry during World War II.

Buoyancy and aerodynamics are apt metaphors for investing in transformational innovations today. Investors must be wary of buoyancy when investment bubbles form and confirm that any outperformance isn’t just hot air. However, sound aerodynamics are the market equivalent of strong fundamentals like strong growth in revenues and earnings, justifying higher altitudes. 

With that, please sit back, relax, and enjoy the flight in this, the third edition of our 250 years of US innovation series exploring the transformational innovation of aviation.

Top of the Morning: Into the wild blue yonder - Aviation

18 Dec 2025  |  22 min

The 250 years of U.S. innovation publication series highlights examples of how transformational innovation has been an engine of U.S. economic growth since the nation’s founding. Today, we explore the history of aviation in the U.S. by referencing the next publication of the series: Into the wild blue yonder - Aviation. Featured are Kurt Reiman, Head of Fixed Income Americas, and Nathaniel Gabrial, U.S. Industrials and Materials Sector Strategist, UBS Chief Investment Office. Host: Daniel Cassidy

26 Nov 2025

Ulrike Hoffmann-Burchardi, Chief Investment Officer Americas and Global Head of Equities; Kurt Reiman, Head of Fixed Income, CIO Americas; Jay Dobson, James Dobson, Equity Strategist, Energy & Utilities, CIO Americas

The dawn of electrification

In October, we launched our 250 years of US innovation series with a focus on the transcontinental railroad. This month, I’m excited to present the second edition, featuring the dawn of electrification.

The incandescent lightbulb was a bright idea that sparked electrification. After nearly 3,000 prototypes, Thomas Edison created an incandescent lightbulb in 1879 with a carbonized cotton-thread filament that burned for 13 hours. His invention would receive US patent number 223,898 on 27 January 1880. Perhaps unsurprisingly, Edison got his start working in the growth industries of his era: railroads and telegraphs. Some of those early experiences spurred him to tinker and experiment to find new innovations, like the quadruplex telegraph that enabled four messages to be sent simultaneously. The same curiosity that spawned the lightbulb led to less well known but equally important advances in power distribution like generators, meters, and wiring switches. His overall approach to invention and entrepreneurship would inspire an entire new school of thought, embodied by people such as Henry Ford.

The lightbulb was a revolutionary invention, but it took more than a decade for electrification and its benefits to become essential for businesses and households—a necessity that sparked a wave of follow-on inventions. By the early 1900s, when electricity was just beginning to power commerce, the benefits of the telegraph and the transcontinental railroad were also becoming more entrenched. Productivity would rise rapidly in urban areas before climbing nationally in the 1920s as these transformational technologies reshaped the industrial and agricultural landscape. Electrification would spur yet another wave of productivity growth in the 1950s with the invention of household appliances.

Today, electric utilities are experiencing another significant growth phase—this time to power artificial intelligence (AI) and the energy needs for reshored manufacturing and electrification. Investors must now reconsider the electric utility sector, as its performance profile appears slightly less defensive and is instead powered by structural growth in revenues and earnings resulting from electrification and AI. In other words, the sector is experiencing accelerating power demand growth and investment like its dawning in the early light of the 1900s.

Top of the Morning: By the dawn's early light - Electrification

17 Dec 2025  |  26 min

The 250 years of U.S. innovation publication series highlights examples of how transformational innovation has been an engine of U.S. economic growth since the nation’s founding. Today, we explore the history of electrification in the U.S. by referencing the next publication of the series: By the dawn's early light - Electrification. Featured are Kurt Reiman, Head of Fixed Income Americas, and Jay Dobson, U.S. Energy and Utilities Sector Strategist, UBS Chief Investment Office. Host: Daniel Cassidy

27 Oct 2025

Ulrike Hoffmann-Burchardi, Chief Investment Officer Americas and Global Head of Equities; Kurt Reiman, Head of Fixed Income, CIO Americas; Nathaniel Gabriel, Equity Strategist, Industrials & Materials, CIO Americas

The spirit of enterprise

“No sooner do you set foot upon the American soil than you are stunned by a kind of tumult,” wrote Alexis de Tocqueville, taken by the pace of a young republic, in 1835’s Democracy in America. I, too, was stunned. Like Tocqueville, having been educated in Europe, America appeared to have turned things upside down. The question of “why could it work?” rather than “why will it not work?” seemed reckless yet enticing.

For the first time as a young professional, I stepped onto American soil in 2000 for a narrowly defined purpose—a project involving data, analytics, and a new way of systematic equity investing—much like Tocqueville, who crossed the Atlantic in 1831 under the banner of studying the US penitentiary system. I did not expect, however, to be swept into the same whirlwind that struck Tocqueville nearly two centuries earlier. 

Everywhere I turned, I witnessed what Tocqueville described as “the spirit of improvement always abroad in the United States.” In conversations with investors, business leaders, and start-up entrepreneurs, I encountered the same impatience with the present. I saw associations—what Tocqueville had once described as “the art of pursuing in common the object of their common desires”—not only in civic groups but also in venture capital and incubators.

This passion, still vivid today, extends beyond material wealth. It is about impact, legacy, and the drive to leave something behind that is bigger than oneself. While I came to America for a project, I stayed because of this restless, inventive spirit that is part fever, part discipline, and part collaboration.

The almost 250-year history of the United States stands as a testament to the power of its unique democratic and societal spirit of entrepreneurship. Leading up to 4 July 2026, we will celebrate the semiquincentennial with a series of reports highlighting prime examples of uniquely American innovation and entrepreneurship that have not only transformed the US economic landscape but also impacted the world in profound ways. 

I’m delighted to share our inaugural report, which takes us back to the mid-1800s and the building of the transcontinental railroad. This significant and foundational innovation revolutionized transportation and commerce, but only after overcoming numerous logistical and geographic challenges.

Transformational innovation has been an engine of US economic growth since the nation’s founding and is one of the three perspectives that shape our investment views. A review of the past—the capex cycles, capital flows, productivity booms, and wealth creation—suggests many parallels to what lies ahead, especially in the areas of AI, electrification, and longevity. This arc is what fascinates me most: the chance to learn from history in order to guide portfolios through the next wave of structural change.

Top of the Morning: From sea to shining sea - The transcontinental railroad

10 Nov 2025  |  22 min

The 250 years of US innovation publication series highlights examples of how transformational innovation has been an engine of US economic growth since the nation’s founding. Today, we explore the history of America’s railroad by referencing the inaugural publication of the series: From sea to shining sea: The transcontinental railroad. Featured are Kurt Reiman, Head of Fixed Income Americas, and Nathaniel Gabriel, US Industrials and Materials Sector Strategist, UBS Chief Investment Office. Host: Daniel Cassidy