From Tuscaloosa, Alabama:
I-59 N/I-20 E toward Birmingham. Merge onto I-459 N via exit number 106 toward Gadsen/Atlanta, then merge onto I-65 N via exit number 15 toward Birmingham. Merge onto Montgomery Highway/US-31 N/AL-3 N via exit number 252 toward Vestavia Hills, then merge onto Shades Creek Parkway/AL-149 S. End at 800 Shades Creek Pkwy Birmingham AL.

From Huntsville, Alabama:
I-565 W via the ramp- on the left. Merge onto I-65 S via exit number 1 toward Birmingham, then merge onto I-59 N/I-20 E via exit number 261A- on the left- toward Gadsen/ Atlanta. Merge onto US-280 E/US-31 S/Elton B Stephens Exitway via exit number 126A. Merge onto US-280 E/AL-38 E toward Sylacauga/ Zoo-Gardens, then take the AL-149 ramp toward Homewood/Mountain Brook and turn Right onto Shades Creek Parkway/AL-149 S. End at 800 Shades Creek Parkway Birmingham.

From Montgomery, Alabama:
I-65 N toward Birmingham and merge onto Montgomery Highway/ US-31 N/AL-3 N via exit number 252 toward Vestavia Hills. Then merge onto Shades Creek Parkway/AL-149 S. End at 800 Shades Creek Parkway Birmingham AL.

From Atlanta, Georgia:
I-20 W. Merge onto I-459 S via exit number 136 toward Montgomery/ Tuscaloosa. Then merge onto US-280 W/AL-38 W via exit number 19 toward Mountain Brook and take the AL-149 ramp toward Homewood/ Mountain Brook. Turn Left onto Shades Creek Parkway/AL-149 N, then make a U-Turn onto Shades Creek Parkway/AL-149 S. 0. End at 800 Shades Creek Parkway Birmingham AL.